ADCK3 Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP. Belongs to the protein kinase superfamily. ADCK protein kinase family. Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ABC1 family; ABC1-A subfamily; ATYPICAL group; EC 2.7.11.-; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component:  integral component of membrane; mitochondrion
Molecular Function:  ADP binding; ATP binding; kinase activity; protein binding
Biological Process:  phosphorylation; ubiquinone biosynthetic process
Disease: Coenzyme Q10 Deficiency, Primary, 4
Reference #:  Q8NI60 (UniProtKB)
Alt. Names/Synonyms: aarF domain-containing protein kinase 3; ADCK3; ARCA2; atypical kinase ADCK3, mitochondrial; Atypical kinase COQ8A, mitochondrial; CABC1; Chaperone activity of bc1 complex-like; Chaperone activity of bc1 complex-like, mitochondrial; chaperone, ABC1 activity of bc1 complex homolog; chaperone, ABC1 activity of bc1 complex homolog (S. pombe); chaperone, ABC1 activity of bc1 complex like; Chaperone-ABC1-like; Coenzyme Q protein 8A; coenzyme Q8 homolog; coenzyme Q8A; COQ10D4; COQ8; COQ8A; MGC4849; SCAR9
Gene Symbols: COQ8A
Molecular weight: 71,950 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
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ADCK3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene