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EDA2R
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: Xq12 |
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Cellular Component:
membrane; plasma membrane
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Molecular Function:
protein binding; signaling receptor activity; tumor necrosis factor receptor activity
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Biological Process:
ectodermal cell differentiation; epidermis development; intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity; tumor necrosis factor-mediated signaling pathway
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Reference #:
Q9HAV5
(UniProtKB)
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Alt. Names/Synonyms: ectodysplasin A2 receptor; EDA-A2 receptor; EDA-A2R; EDA2R; EDAA2R; TNFRSF27; TNR27; Tumor necrosis factor receptor superfamily member 27; tumor necrosis factor receptor superfamily member XEDAR; X-linked ectodysplasin-A2 receptor; XEDAR
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Gene Symbols: EDA2R
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Molecular weight:
32,759 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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