CREB3L3 Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; integral component of membrane; membrane; nucleoplasm; nucleus
Molecular Function:  cAMP response element binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  endoplasmic reticulum unfolded protein response; positive regulation of acute inflammatory response; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Reference #:  Q68CJ9 (UniProtKB)
Alt. Names/Synonyms: cAMP responsive element binding protein 3 like 3; cAMP responsive element binding protein 3-like 3; cAMP-responsive element-binding protein 3-like protein 3; cAMP-responsive element-binding protein, hepatic-specific; CR3L3; CREB-H; CREB/ATF family transcription factor; CREB3L3; CREBH; Cyclic AMP-responsive element-binding protein 3-like protein 3; HYST1481; MGC126553; MGC126557; Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H
Gene Symbols: CREB3L3
Molecular weight: 49,077 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB