ADCK4 Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration. Belongs to the protein kinase superfamily. ADCK protein kinase family. Widely expressed, including renal podocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ABC1 family; ABC1-A subfamily; ATYPICAL group; EC 2.7.-.-; EC 2.7.11.-; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  cytosol; integral component of membrane; mitochondrion; plasma membrane
Molecular Function:  ATP binding
Biological Process:  cerebellar Purkinje cell layer morphogenesis; ubiquinone biosynthetic process
Disease: Nephrotic Syndrome, Type 9
Reference #:  Q96D53 (UniProtKB)
Alt. Names/Synonyms: aarF domain containing kinase 4; aarF domain-containing protein kinase 4; ADCK4; Atypical kinase COQ8B, mitochondrial; coenzyme Q8B; COQ8B; FLJ12229; NPHS9
Gene Symbols: COQ8B
Molecular weight: 60,069 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
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ADCK4

Protein Structure Not Found.

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