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ABHD4
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.1.-; Hydrolase |
| Chromosomal Location of human Ortholog: 14q11.2 |
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Cellular Component:
endoplasmic reticulum membrane; lipid droplet; mitochondrion
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Molecular Function:
hydrolase activity; lysophosphatidic acid acyltransferase activity; lysophospholipase activity; protein binding
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Biological Process:
lipid catabolic process; lipid homeostasis; N-acylphosphatidylethanolamine metabolic process; phosphatidic acid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling
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Reference #:
Q8TB40
(UniProtKB)
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Alt. Names/Synonyms: (Lyso)-N-acylphosphatidylethanolamine lipase; ABH4; ABHD4; abhydrolase domain containing 4; abhydrolase domain containing 4, N-acyl phospholipase B; Abhydrolase domain-containing protein 4; Alpha/beta hydrolase domain-containing protein 4; Alpha/beta-hydrolase 4; FLJ12816; Lyso-N-acylphosphatidylethanolamine lipase; Protein ABHD4
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Gene Symbols: ABHD4
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Molecular weight:
38,794 Da
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Basal Isoelectric point:
7.13
Predict pI for various phosphorylation states
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