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ABCB7
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, ABC family |
| Chromosomal Location of rat Ortholog: Xq22 |
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Cellular Component:
membrane; mitochondrial inner membrane; mitochondrion
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Molecular Function:
ABC-type iron-sulfur cluster transporter activity; ABC-type transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled transmembrane transporter activity; protein binding; protein homodimerization activity
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Biological Process:
intracellular iron ion homeostasis; iron ion transmembrane transport; iron-sulfur cluster assembly; iron-sulfur cluster export from the mitochondrion; negative regulation of reactive oxygen species biosynthetic process; positive regulation of heme biosynthetic process; positive regulation of iron-sulfur cluster assembly; transmembrane transport
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Reference #:
Q704E8
(UniProtKB)
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Alt. Names/Synonyms: ABC transporter 7 protein; Abcb7; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; ATP-binding cassette, sub-family B, member 7, mitochondrial; Iron-sulfur clusters transporter ABCB7, mitochondrial
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Gene Symbols: Abcb7
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Molecular weight:
82,558 Da
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Basal Isoelectric point:
9.35
Predict pI for various phosphorylation states
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