A6r Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Ubiquitously expressed (at protein level). Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.2
Cellular Component:  cytoplasm; filopodium; growth cone; lamellipodium; myofibril; perinuclear region of cytoplasm; stereocilium
Molecular Function:  actin monomer binding; ATP binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein kinase C binding
Biological Process:  barbed-end actin filament capping; cell projection organization; cellular response to growth factor stimulus; cellular response to retinoic acid; negative regulation of actin filament polymerization; positive regulation of axon extension; positive regulation of lamellipodium assembly; positive regulation of neuron projection development; regulation of actin cytoskeleton organization; regulation of microvillus length; sequestering of actin monomers
Reference #:  Q6IBS0 (UniProtKB)
Alt. Names/Synonyms: A6-related protein; A6r; A6RP; hA6RP; MSTP011; Protein tyrosine kinase 9-like; protein tyrosine kinase 9-like (A6-related protein); PTK9L; PTK9L protein tyrosine kinase 9-like (A6-related protein); TWF2; twinfilin actin binding protein 2; twinfilin, actin-binding protein, homolog 2; twinfilin, actin-binding protein, homolog 2 (Drosophila); Twinfilin-1-like protein; Twinfilin-2
Gene Symbols: TWF2
Molecular weight: 39,548 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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