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NADK2
Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. Belongs to the NAD kinase family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.23 |
| Chromosomal Location of human Ortholog: 5p13.2 |
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Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
ATP binding; NAD+ kinase activity; protein homodimerization activity
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Biological Process:
NAD metabolic process; NADP biosynthetic process; phosphorylation
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Disease: 2,4-dienoyl-coa Reductase Deficiency
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Reference #:
Q4G0N4
(UniProtKB)
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Alt. Names/Synonyms: C5orf33; DECRD; FLJ30596; MGC43298; Mitochondrial NAD kinase; MNADK; NAD kinase 2, mitochondrial; NAD kinase domain-containing protein 1, mitochondrial; NADK2; NADKD1; NAKD2; UPF0465 protein C5orf33
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Gene Symbols: NADK2
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Molecular weight:
49,433 Da
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Basal Isoelectric point:
8.46
Predict pI for various phosphorylation states
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