NADK2 Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. Belongs to the NAD kinase family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC
Chromosomal Location of human Ortholog: 5p13.2
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  ATP binding; NAD+ kinase activity; protein homodimerization activity
Biological Process:  NAD metabolic process; NADP biosynthetic process; phosphorylation
Disease: 2,4-dienoyl-coa Reductase Deficiency
Reference #:  Q4G0N4 (UniProtKB)
Alt. Names/Synonyms: C5orf33; DECRD; FLJ30596; MGC43298; Mitochondrial NAD kinase; MNADK; NAD kinase 2, mitochondrial; NAD kinase domain-containing protein 1, mitochondrial; NADK2; NADKD1; NAKD2; UPF0465 protein C5orf33
Gene Symbols: NADK2
Molecular weight: 49,433 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein