A6 Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q12
Cellular Component:  actin cytoskeleton; cell-cell junction; cytosol; filopodium; myofibril; perinuclear region of cytoplasm
Molecular Function:  actin binding; actin monomer binding; ATP binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding
Biological Process:  negative regulation of actin filament polymerization; peptidyl-tyrosine phosphorylation; positive regulation of cardiac muscle hypertrophy; regulation of actin phosphorylation; sequestering of actin monomers
Reference #:  Q12792 (UniProtKB)
Alt. Names/Synonyms: A6; A6 protein tyrosine kinase; MGC23788; MGC41876; Protein A6; Protein tyrosine kinase 9; PTK9; PTK9 protein tyrosine kinase 9; TWF1; twinfilin actin binding protein 1; twinfilin, actin-binding protein, homolog 1; twinfilin, actin-binding protein, homolog 1 (Drosophila); Twinfilin-1
Gene Symbols: TWF1
Molecular weight: 40,283 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein