Abi-1 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. Belongs to the ABI family. Widely expressed, with highest expression in brain. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q12.3
Cellular Component:  cell junction; cell leading edge; cytoplasm; cytoskeleton; filopodium; filopodium tip; glutamatergic synapse; growth cone; lamellipodium; neuron projection; nucleus; postsynaptic density; postsynaptic membrane; SCAR complex
Molecular Function:  protein binding; protein tyrosine kinase activator activity; SH3 domain binding; transcription factor binding
Biological Process:  actin polymerization or depolymerization; dendrite morphogenesis; lamellipodium morphogenesis; megakaryocyte development; peptidyl-tyrosine phosphorylation; positive regulation of protein tyrosine kinase activity; postsynapse to nucleus signaling pathway; somitogenesis
Reference #:  Q9QZM5 (UniProtKB)
Alt. Names/Synonyms: Abelson interactor 1; Abi-1; Abi1; Abl interactor 1; abl-interactor 1; e3B1; eps8 binding protein (e3B1), alternatively spliced; Eps8 SH3 domain-binding protein; Eps8-binding protein
Gene Symbols: Abi1
Molecular weight: 51,705 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene