EEF2K Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. Belongs to the protein kinase superfamily. Alpha-type protein kinase family. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Alpha family; EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation; eEF2K subfamily
Chromosomal Location of Human Ortholog: 1q36
Cellular Component:  dendritic spine; postsynaptic density
Molecular Function:  ATP binding; calcium ion binding; calmodulin binding; elongation factor-2 kinase activity
Biological Process:  cellular response to anoxia; cellular response to brain-derived neurotrophic factor stimulus; cellular response to calcium ion; cellular response to cAMP; cellular response to insulin stimulus; negative regulation of apoptotic process; positive regulation of dendritic spine morphogenesis; positive regulation of endocytosis; positive regulation of synapse assembly; protein autophosphorylation; regulation of protein autophosphorylation; response to ischemia; response to prolactin
Reference #:  P70531 (UniProtKB)
Alt. Names/Synonyms: Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Eef2k; EF2K; elongation factor 2 kinase; Eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; SMEF2K
Gene Symbols: Eef2k
Molecular weight: 81,489 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene