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FASTK
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. Belongs to the FAST protein kinase family. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: ATYPICAL group; EC 2.7.11.8; FAST family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical |
| Chromosomal Location of mouse Ortholog: 5|5 A3 |
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Cellular Component:
mitochondrial matrix; nuclear speck; ribonucleoprotein granule
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Molecular Function:
ATP binding; Fas-activated serine/threonine kinase activity; kinase activity; nucleotide binding; protein serine/threonine kinase activity; RNA binding; transferase activity
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Biological Process:
apoptotic process; mitochondrial RNA processing; phosphorylation; protein phosphorylation; regulation of mitochondrial mRNA stability; regulation of RNA splicing
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Reference #:
Q9JIX9
(UniProtKB)
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Alt. Names/Synonyms: 0610011K02Rik; 610011K02Rik; Fas-activated serine/threonine kinase; FAST kinase; Fastk; OTTMUSP00000028758
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Gene Symbols: Fastk
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Molecular weight:
57,726 Da
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Basal Isoelectric point:
9.7
Predict pI for various phosphorylation states
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