NSAP1 Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 6q14.3
Cellular Component:  catalytic step 2 spliceosome; CRD-mediated mRNA stability complex; endoplasmic reticulum; GAIT complex; histone pre-mRNA 3'end processing complex; nucleoplasm; ribonucleoprotein complex
Molecular Function:  poly(A) binding; protein binding
Biological Process:  cellular response to interferon-gamma; CRD-mediated mRNA stabilization; mRNA splicing, via spliceosome; negative regulation of translation; RNA processing; RNA splicing; viral process
Reference #:  O60506 (UniProtKB)
Alt. Names/Synonyms: dJ3J17.2; FLJ31626; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; GRYRBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; hnRNP-Q; HNRNPQ; HNRPQ; HNRPQ1; NS1-associated protein 1; NSAP1; PP68; synaptotagmin binding cytoplasmic RNA interacting protein; synaptotagmin binding, cytoplasmic RNA interacting protein; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; SYNCRIP
Gene Symbols: SYNCRIP
Molecular weight: 69,603 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NSAP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein