DKK1 Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Belongs to the dickkopf family. Placenta. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 10q21.1
Cellular Component:  early endosome membrane; extracellular region; extracellular space; plasma membrane
Molecular Function:  co-receptor binding; growth factor activity; low-density lipoprotein particle receptor binding; protein binding; receptor antagonist activity
Biological Process:  canonical Wnt signaling pathway; cell morphogenesis involved in differentiation; embryonic limb morphogenesis; endoderm formation; face morphogenesis; forebrain development; hair follicle development; learning or memory; limb development; mesoderm formation; motor learning; negative regulation of apoptotic process; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; negative regulation of cardiac muscle cell differentiation; negative regulation of mesodermal cell fate specification; negative regulation of neuron projection development; negative regulation of ossification; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of presynapse assembly; negative regulation of protein binding; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; positive regulation of cell death; positive regulation of gene expression; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; positive regulation of JUN kinase activity; positive regulation of midbrain dopaminergic neuron differentiation; positive regulation of neuron death; positive regulation of tau-protein kinase activity; positive regulation of Wnt signaling pathway, calcium modulating pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; regulation of dopaminergic neuron differentiation; regulation of endodermal cell fate specification; regulation of receptor internalization; regulation of synaptic transmission, glutamatergic; response to retinoic acid; synapse pruning; Wnt signaling pathway involved in somitogenesis
Reference #:  O94907 (UniProtKB)
Alt. Names/Synonyms: dickkopf 1 homolog; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; Dkk-1; DKK1; hDkk-1; SK
Gene Symbols: DKK1
Molecular weight: 28,672 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene