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PXN
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis |
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Cellular Component:
cell cortex; cytosol; focal adhesion; plasma membrane; stress fiber
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Molecular Function:
metal ion binding; protein binding; transcription coregulator activity; vinculin binding
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Biological Process:
cell-matrix adhesion; DNA-templated transcription; endothelial cell migration; response to muscle stretch; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway
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Reference #:
P49024
(UniProtKB)
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Alt. Names/Synonyms: Paired box protein Pax-1; PAX-1; PAXI; Paxillin; PXN
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Gene Symbols: PXN
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Molecular weight:
61,243 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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