|
PXN
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis |
|
Cellular Component:
cell; cytoplasm; cytosol; focal adhesion; plasma membrane; stress fiber
|
|
Molecular Function:
metal ion binding; protein binding; transcription coregulator activity; vinculin binding
|
|
Biological Process:
cell-matrix adhesion; endothelial cell migration; response to muscle stretch; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway
|
|
Reference #:
P49024
(UniProtKB)
|
|
Alt. Names/Synonyms: Paired box protein Pax-1; PAX-1; PAXI; Paxillin; PXN
|
|
Gene Symbols: PXN
|
|
Molecular weight:
61,243 Da
|
|
Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
ErbB/HER Signaling
|
Growth And Differentiation Control by MAPKs
|
PI3K/Akt Signaling
|
