PXN Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component:  cell cortex; cytosol; focal adhesion; plasma membrane; stress fiber
Molecular Function:  metal ion binding; protein binding; transcription coregulator activity; vinculin binding
Biological Process:  cell-matrix adhesion; DNA-templated transcription; endothelial cell migration; response to muscle stretch; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway
Reference #:  P49024 (UniProtKB)
Alt. Names/Synonyms: Paired box protein Pax-1; PAX-1; PAXI; Paxillin; PXN
Gene Symbols: PXN
Molecular weight: 61,243 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene