PLSCR2 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain. Belongs to the phospholipid scramblase family. Expression of isoform 1 seems restricted to testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 3q24
Cellular Component:  integral component of membrane; nucleus; plasma membrane
Molecular Function:  calcium ion binding; phospholipid scramblase activity
Biological Process:  phospholipid scrambling
Reference #:  Q9NRY7 (UniProtKB)
Alt. Names/Synonyms: Ca(2+)-dependent phospholipid scramblase 2; Phospholipid scramblase 2; PL scramblase 2; PLSCR2
Gene Symbols: PLSCR2
Molecular weight: 33,504 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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