KRTAP5-8
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Belongs to the KRTAP type 5 family. Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles. Note: This description may include information from UniProtKB.
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Chromosomal Location of human Ortholog: 11q13.4 |
Cellular Component:
cytosol; intermediate filament
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Molecular Function:
protein binding; structural constituent of skin epidermis
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Reference #:
O75690
(UniProtKB)
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Alt. Names/Synonyms: KAP5.8; keratin associated protein 5-8; keratin, ultra high-sulfur matrix protein B; keratin, ultrahigh sulfur, B; Keratin-associated protein 5-8; keratin-associated protein 5.8; KRA58; KRTAP5-2; KRTAP5-8; KRTAP5.8; UHS keratin B; UHS KerB; UHS KERB-like protein; UHSKB; UHSKerB; ultrahigh sulfur keratin-associated protein 5.8
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Gene Symbols: KRTAP5-8
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Molecular weight:
17,519 Da
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Basal Isoelectric point:
8.24
Predict pI for various phosphorylation states
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