UBE3C E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 7q36.3
Cellular Component:  proteasome complex
Molecular Function:  protein binding; ubiquitin protein ligase activity
Biological Process:  protein K29-linked ubiquitination; protein K48-linked ubiquitination; protein polyubiquitination; ubiquitin-dependent protein catabolic process
Disease: Neurodevelopmental Disorder With Absent Speech And Movement And Behavioral Abnormalities
Reference #:  Q15386 (UniProtKB)
Alt. Names/Synonyms: HECT-type ubiquitin transferase E3C; HectH2; KIAA0010; KIAA10; UBE3C; ubiquitin protein ligase E3C; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C
Gene Symbols: UBE3C
Molecular weight: 123,923 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene