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UBE3C
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 7q36.3 |
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Cellular Component:
proteasome complex
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Molecular Function:
protein binding; ubiquitin protein ligase activity
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Biological Process:
protein K29-linked ubiquitination; protein K48-linked ubiquitination; protein polyubiquitination; ubiquitin-dependent protein catabolic process
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Disease: Neurodevelopmental Disorder With Absent Speech And Movement And Behavioral Abnormalities
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Reference #:
Q15386
(UniProtKB)
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Alt. Names/Synonyms: HECT-type ubiquitin transferase E3C; HectH2; KIAA0010; KIAA10; UBE3C; ubiquitin protein ligase E3C; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C
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Gene Symbols: UBE3C
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Molecular weight:
123,923 Da
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Basal Isoelectric point:
6.27
Predict pI for various phosphorylation states
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