TOP2A Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Belongs to the type II topoisomerase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Isomerase
Chromosomal Location of mouse Ortholog: 11 D|11 62.91 cM
Cellular Component:  centriole; chromosome, centromeric region; condensed chromosome; cytoplasm; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; male germ cell nucleus; nuclear chromosome; nucleolus; nucleoplasm; nucleus; protein-containing complex; ribonucleoprotein complex
Molecular Function:  ATP binding; ATP-dependent activity, acting on DNA; chromatin binding; DNA binding; DNA binding, bending; DNA topoisomerase activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; enzyme binding; histone deacetylase binding; isomerase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding; sequence-specific DNA binding; ubiquitin binding
Biological Process:  apoptotic chromosome condensation; cellular response to DNA damage stimulus; chromosome condensation; chromosome segregation; DNA ligation; DNA metabolic process; DNA topological change; embryonic cleavage; female meiosis chromosome separation; female meiotic nuclear division; hematopoietic progenitor cell differentiation; negative regulation of DNA duplex unwinding; positive regulation of apoptotic process; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; resolution of meiotic recombination intermediates; rhythmic process; sister chromatid segregation
Reference #:  Q01320 (UniProtKB)
Alt. Names/Synonyms: DNA topoisomerase 2-alpha; DNA Topoisomerase II alpha; DNA topoisomerase II, alpha isozyme; OTTMUSP00000006845; Top; Top-2; Top2; Top2a; topoisomerase (DNA) II alpha
Gene Symbols: Top2a
Molecular weight: 172,790 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene