|
TOP2A
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Belongs to the type II topoisomerase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 5.99.1.3; Isomerase |
| Chromosomal Location of mouse Ortholog: 11 D|11 62.91 cM |
|
Cellular Component:
centriole; chromosome, centromeric region; condensed chromosome; cytoplasm; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; male germ cell nucleus; nuclear chromosome; nucleolus; nucleoplasm; nucleus; protein-containing complex; ribonucleoprotein complex
|
|
Molecular Function:
ATP binding; ATP-dependent activity, acting on DNA; chromatin binding; DNA binding; DNA binding, bending; DNA topoisomerase activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; enzyme binding; histone deacetylase binding; isomerase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding; sequence-specific DNA binding; ubiquitin binding
|
|
Biological Process:
apoptotic chromosome condensation; cellular response to DNA damage stimulus; chromosome condensation; chromosome segregation; DNA ligation; DNA metabolic process; DNA topological change; embryonic cleavage; female meiosis chromosome separation; female meiotic nuclear division; hematopoietic progenitor cell differentiation; negative regulation of DNA duplex unwinding; positive regulation of apoptotic process; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; resolution of meiotic recombination intermediates; rhythmic process; sister chromatid segregation
|
|
Reference #:
Q01320
(UniProtKB)
|
|
Alt. Names/Synonyms: DNA topoisomerase 2-alpha; DNA Topoisomerase II alpha; DNA topoisomerase II, alpha isozyme; OTTMUSP00000006845; Top; Top-2; Top2; Top2a; topoisomerase (DNA) II alpha
|
|
Gene Symbols: Top2a
|
|
Molecular weight:
172,790 Da
|
|
Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
|
|
CST Pathways:
G2/M DNA Damage Checkpoint
|
