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KCNJ8
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily. Predominantly detected in fetal and adult heart. Note: This description may include information from UniProtKB.
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| Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of Human Ortholog: 4q44 |
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Cellular Component:
intracellular membrane-bounded organelle; inward rectifying potassium channel; membrane; mitochondrion; myofibril; sarcolemma
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Molecular Function:
ATP binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding; sulfonylurea receptor binding; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
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Biological Process:
defense response to virus; heart development; kidney development; membrane repolarization during ventricular cardiac muscle cell action potential; potassium ion import across plasma membrane; potassium ion transport; regulation of ion transmembrane transport; response to exogenous dsRNA; response to lipopolysaccharide
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Reference #:
Q63664
(UniProtKB)
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Alt. Names/Synonyms: ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive); Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); IRK8; Kcnj8; Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; potassium inwardly-rectifying channel, subfamily J, member 8; uKATP-1; UKATP1
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Gene Symbols: Kcnj8
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Molecular weight:
47,963 Da
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Basal Isoelectric point:
9.35
Predict pI for various phosphorylation states
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