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PECAM-1
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis. Isoform Delta15: Does not protect against apoptosis. Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 11|11 E1 |
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Cellular Component:
anchoring junction; cell periphery; cell surface; cell-cell contact zone; cell-cell junction; cytoplasm; external side of plasma membrane; extracellular space; membrane; membrane raft; plasma membrane; protein-containing complex; ruffle; smooth muscle contractile fiber
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Molecular Function:
protein binding; protein homodimerization activity; protein phosphatase binding; transmembrane signaling receptor activity
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Biological Process:
angiogenesis; bicellular tight junction assembly; cell adhesion; cell surface receptor signaling pathway; cell-cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; diapedesis; endothelial cell migration; endothelial cell morphogenesis; endothelial cell-matrix adhesion; establishment of endothelial barrier; homophilic cell adhesion via plasma membrane adhesion molecules; leukocyte cell-cell adhesion; monocyte extravasation; negative regulation of actin filament polymerization; negative regulation of GTPase activity; negative regulation of peptidyl-tyrosine phosphorylation; neutrophil extravasation; phagocytosis; positive regulation of cell migration; positive regulation of cellular extravasation; positive regulation of leukocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein localization to cell-cell junction; positive regulation of protein phosphorylation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of cell migration; Rho protein signal transduction; wound healing
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Reference #:
Q08481
(UniProtKB)
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Alt. Names/Synonyms: C85791; Cd31; MGC102160; OTTMUSP00000003452; OTTMUSP00000003454; PECA1; Pecam; PECAM-1; PECAM-1/CD31; Pecam1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1
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Gene Symbols: Pecam1
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Molecular weight:
81,263 Da
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Basal Isoelectric point:
6.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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