SPTAN1 iso2 Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component:  cytosol; extracellular region; intracellular membrane-bounded organelle; membrane; microtubule cytoskeleton; specific granule lumen; spectrin; tertiary granule lumen
Molecular Function:  actin binding; calcium ion binding; calmodulin binding; protein binding; structural constituent of cytoskeleton
Biological Process:  actin filament capping; axon guidance; cytoskeleton organization; ER to Golgi vesicle-mediated transport; MAPK cascade; neutrophil degranulation
Reference #:  Q13813-2 (UniProtKB)
Alt. Names/Synonyms: alpha-fodrin; Alpha-II spectrin; EIEE5; epididymis secretory sperm binding protein; Fodrin alpha chain; NEAS; Spectrin alpha chain, non-erythrocytic 1; spectrin alpha, non-erythrocytic 1; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); spectrin, non-erythroid alpha; spectrin, non-erythroid alpha chain; Spectrin, non-erythroid alpha subunit; SPTA2; SPTAN1; SPTAN1 iso2; SPTN1
Gene Symbols: SPTAN1
Molecular weight: 285,094 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Select Structure to View Below

SPTAN1 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein