RGS14 Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of Human Ortholog: 17p14
Cellular Component:  cell junction; centrosome; cytoplasm; dendrite; dendritic spine; glutamatergic synapse; microtubule; nuclear body; nucleus; plasma membrane; PML body; postsynaptic density; postsynaptic membrane; spindle; spindle pole
Molecular Function:  G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; GTPase activating protein binding; GTPase activator activity; microtubule binding; protein binding; protein kinase binding; receptor signaling complex scaffold activity
Biological Process:  cell division; chromosome segregation; intracellular signal transduction; learning; long-term memory; long-term synaptic potentiation; mitotic cell cycle; modulation of chemical synaptic transmission; negative regulation of ERK1 and ERK2 cascade; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of synaptic plasticity; nucleocytoplasmic transport; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of neurogenesis; positive regulation of signal transduction; regulation of DNA-templated transcription in response to stress; regulation of G protein-coupled receptor signaling pathway; response to oxidative stress; spindle organization; visual learning; zygote asymmetric cell division
Reference #:  O08773 (UniProtKB)
Alt. Names/Synonyms: MGC108631; Regulator of G-protein signaling 14; RGS14
Gene Symbols: Rgs14
Molecular weight: 59,492 Da
Basal Isoelectric point: 7.14  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene