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SDH5
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. Belongs to the SDHAF2 family. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 11q12.2 |
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Cellular Component:
cytosol; mitochondrial matrix; mitochondrion; nucleolus
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Molecular Function:
protein binding
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Biological Process:
mitochondrial electron transport, succinate to ubiquinone; mitochondrial respiratory chain complex II assembly; negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; protein dephosphorylation; protein-FAD linkage; tricarboxylic acid cycle
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Disease: Paragangliomas 2
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Reference #:
Q9NX18
(UniProtKB)
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Alt. Names/Synonyms: C11orf79; FLJ20487; hSDH5; paraganglioma or familial glomus tumors 2; PGL2; SDH assembly factor 2; SDH5; SDHAF2; SDHF2; Succinate dehydrogenase assembly factor 2, mitochondrial; succinate dehydrogenase complex assembly factor 2; Succinate dehydrogenase subunit 5, mitochondrial
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Gene Symbols: SDHAF2
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Molecular weight:
19,599 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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