IL-1RB Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q11.2
Cellular Component:  cytoplasm; extracellular region; integral component of membrane; plasma membrane
Molecular Function:  interleukin-1 binding; interleukin-1 receptor activity; interleukin-1, type II, blocking receptor activity; protein binding
Biological Process:  cytokine-mediated signaling pathway; immune response; interleukin-1-mediated signaling pathway; negative regulation of cytokine production involved in inflammatory response; negative regulation of interleukin-1 alpha secretion; negative regulation of interleukin-1-mediated signaling pathway; negative regulation of protein processing
Reference #:  P27930 (UniProtKB)
Alt. Names/Synonyms: antigen CDw121b; CD121 antigen-like family member B; CD121b; CDw121b; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RB; IL-1RT-2; IL-1RT2; IL1R2; IL1R2c; IL1RB; interleukin 1 receptor type 2; interleukin 1 receptor type II variant 3; interleukin 1 receptor, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; Interleukin-1 receptor type 2, membrane form; Interleukin-1 receptor type 2, soluble form; Interleukin-1 receptor type II; MGC47725; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII; type II interleukin-1 receptor, beta
Gene Symbols: IL1R2
Molecular weight: 45,421 Da
Basal Isoelectric point: 8.03  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein