HSP105 Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Belongs to the heat shock protein 70 family. Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component:  cytoplasm; cytosol; endocytic vesicle lumen; extracellular region; microtubule; nucleoplasm; protein-containing complex
Molecular Function:  adenyl-nucleotide exchange factor activity; alpha-tubulin binding; ATP binding; protein binding
Biological Process:  chaperone cofactor-dependent protein refolding; positive regulation of MHC class I biosynthetic process; positive regulation of NK T cell activation; receptor-mediated endocytosis; regulation of catalytic activity; regulation of cellular response to heat; response to unfolded protein
Reference #:  Q92598 (UniProtKB)
Alt. Names/Synonyms: Antigen NY-CO-25; DKFZp686M05240; heat shock 105kD alpha; heat shock 105kD beta; heat shock 105kDa protein 1; heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; Heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1; KIAA0201; NY-CO-25
Gene Symbols: HSPH1
Molecular weight: 96,865 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB