RKIP Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. Belongs to the phosphatidylethanolamine-binding protein family. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component:  cytosol
Molecular Function:  enzyme binding; phosphatidylethanolamine binding; protein binding; protein kinase binding; serine-type endopeptidase inhibitor activity
Biological Process:  MAPK cascade; negative regulation of endopeptidase activity
Reference #:  P30086 (UniProtKB)
Alt. Names/Synonyms: HCNP; HCNPpp; Hippocampal cholinergic neurostimulating peptide; Neuropolypeptide h3; PBP; PEBP; PEBP-1; PEBP1; phosphatidylethanolamine binding protein 1; Phosphatidylethanolamine-binding protein 1; prostatic binding protein; Prostatic-binding protein; Raf kinase inhibitor protein; Raf kinase inhibitory protein; RKIP
Gene Symbols: PEBP1
Molecular weight: 21,057 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RKIP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene