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ATP4A
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. Found in gastric mucosa. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: 19q13.12 |
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Cellular Component:
apical plasma membrane; plasma membrane
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATPase-coupled cation transmembrane transporter activity; magnesium ion binding; P-type potassium:proton transporter activity; P-type sodium:potassium-exchanging transporter activity; potassium ion binding
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Biological Process:
cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment or maintenance of transmembrane electrochemical gradient; ion transmembrane transport; pH reduction; potassium ion import across plasma membrane; proton transmembrane transport; regulation of proton transport; response to xenobiotic stimulus; sodium ion export across plasma membrane
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Reference #:
P20648
(UniProtKB)
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Alt. Names/Synonyms: ATP4A; ATP6A; ATPase H+/K+ transporting alpha subunit; ATPase H+/K+ transporting subunit alpha; ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; epididymis secretory sperm binding protein; Gastric H(+)/K(+) ATPase subunit alpha; gastric H+/K+ ATPase alpha subunit; gastric H,K-ATPase alpha subunit; gastric H,K-ATPase catalytic subunit; gastric hydrogen-potassium ATPase; H(+)-K(+)-ATPase alpha subunit; H+/K ATPase pump; hydrogen/potassium-exchanging ATPase 4A; Potassium-transporting ATPase alpha chain 1; Proton pump
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Gene Symbols: ATP4A
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Molecular weight:
114,119 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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