ATP4A Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. Found in gastric mucosa. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of human Ortholog: 19q13.12
Cellular Component:  apical plasma membrane; plasma membrane
Molecular Function:  ATP binding; ATP hydrolysis activity; ATPase-coupled cation transmembrane transporter activity; magnesium ion binding; P-type potassium:proton transporter activity; P-type sodium:potassium-exchanging transporter activity; potassium ion binding
Biological Process:  cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment or maintenance of transmembrane electrochemical gradient; ion transmembrane transport; pH reduction; potassium ion import across plasma membrane; proton transmembrane transport; regulation of proton transport; response to xenobiotic stimulus; sodium ion export across plasma membrane
Reference #:  P20648 (UniProtKB)
Alt. Names/Synonyms: ATP4A; ATP6A; ATPase H+/K+ transporting alpha subunit; ATPase H+/K+ transporting subunit alpha; ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; epididymis secretory sperm binding protein; Gastric H(+)/K(+) ATPase subunit alpha; gastric H+/K+ ATPase alpha subunit; gastric H,K-ATPase alpha subunit; gastric H,K-ATPase catalytic subunit; gastric hydrogen-potassium ATPase; H(+)-K(+)-ATPase alpha subunit; H+/K ATPase pump; hydrogen/potassium-exchanging ATPase 4A; Potassium-transporting ATPase alpha chain 1; Proton pump
Gene Symbols: ATP4A
Molecular weight: 114,119 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene