AMBP
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. Trypstatin is a trypsin inhibitor. In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine. Note: This description may include information from UniProtKB.
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Protein type: Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 9q32 |
Cellular Component:
cell surface; cytosol; endoplasmic reticulum; extracellular region; mitochondrial inner membrane; nuclear membrane; plasma membrane
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Molecular Function:
calcium channel inhibitor activity; calcium oxalate binding; carbohydrate binding; heme binding; IgA binding; oxidoreductase activity; protein binding; protein homodimerization activity; serine-type endopeptidase inhibitor activity
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Biological Process:
cell adhesion; female pregnancy; heme catabolic process; negative regulation of immune response; negative regulation of JNK cascade; negative regulation of peptidase activity
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Reference #:
P02760
(UniProtKB)
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Alt. Names/Synonyms: A1M; Alpha-1 microglycoprotein; Alpha-1-microglobulin; alpha-1-microglobulin/bikunin precursor; AMBP; Bikunin; Complex-forming glycoprotein heterogeneous in charge; EDC1; growth-inhibiting protein 19; HCP; HI-30; HI30; IATIL; Inter-alpha-trypsin inhibitor light chain; ITI; ITI-LC; ITIL; ITILC; Protein AMBP; Protein HC; Trypstatin; uristatin; Uronic-acid-rich protein; UTI
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Gene Symbols: AMBP
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Molecular weight:
38,999 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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