RKIP Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. Belongs to the phosphatidylethanolamine-binding protein family. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding; Protein kinase, regulatory subunit
Chromosomal Location of rat Ortholog: 12q16
Cellular Component:  apical part of cell; axon terminus; cell surface; cytoplasm; extracellular space; Golgi apparatus; mitochondrial outer membrane; mitochondrion; neuron projection; neuronal cell body; rough endoplasmic reticulum; synaptic vesicle
Molecular Function:  ATP binding; enzyme binding; kinase binding; lipid binding; mitogen-activated protein kinase binding; protein kinase binding; receptor serine/threonine kinase binding; serine-type endopeptidase inhibitor activity; signaling receptor binding
Biological Process:  aging; eating behavior; hippocampus development; MAPK cascade; negative regulation of endopeptidase activity; negative regulation of MAPK cascade; negative regulation of protein phosphorylation; positive regulation of acetylcholine metabolic process; positive regulation of cAMP-mediated signaling; positive regulation of mitotic nuclear division; regulation of neurotransmitter levels; regulation of the force of heart contraction; response to activity; response to calcium ion; response to cAMP; response to corticosterone; response to drug; response to electrical stimulus; response to ethanol; response to heat; response to organic cyclic compound; response to organic substance; response to organonitrogen compound; response to oxidative stress; response to toxic substance; response to wounding; sperm capacitation; spermatid development
Reference #:  P31044 (UniProtKB)
Alt. Names/Synonyms: 23 kDa morphine-binding protein; HCNP; HCNPpp; Hippocampal cholinergic neurostimulating peptide; P23K; Pbp; Pebp; PEBP-1; Pebp1; phosphatidylethanolamine binding protein 1; Phosphatidylethanolamine-binding protein 1; Raf-1 kinase inhibitor protein; Rkip
Gene Symbols: Pebp1
Molecular weight: 20,801 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene