DGKZ iso3 Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes. Activates PIP5K1A activity via generation of phosphatidic acid. Belongs to the eukaryotic diacylglycerol kinase family. Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component:  cytoplasm; glutamatergic synapse; lamellipodium; nuclear speck; nucleus; plasma membrane; postsynaptic density
Molecular Function:  ATP binding; diacylglycerol kinase activity; kinase activity; metal ion binding; NAD+ kinase activity; protein binding
Biological Process:  cell migration; diacylglycerol metabolic process; glycerolipid metabolic process; lipid phosphorylation; phosphatidic acid biosynthetic process; platelet activation; positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; protein kinase C-activating G protein-coupled receptor signaling pathway
Reference #:  Q6ZT25 (UniProtKB)
Alt. Names/Synonyms: DAG kinase zeta; DAGK5; DAGK6; DGK-ZETA; DGKZ; Diacylglycerol kinase; diacylglycerol kinase zeta; diacylglycerol kinase, zeta 104kDa
Gene Symbols: DGKZ
Molecular weight: 106,082 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
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DGKZ iso3

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein