DENND4A iso3 Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component:  cytosol; nucleus
Molecular Function:  DNA binding; Rab guanyl-nucleotide exchange factor activity
Biological Process:  regulation of transcription, DNA-templated
Reference #:  Q7Z401-2 (UniProtKB)
Alt. Names/Synonyms: C-myc promoter-binding protein; C-myc promoter-binding protein isoform 1; DENN domain-containing protein 4A; DENN/MADD domain containing 4A; DENND4A; FLJ33949; IRLB; KIAA0476; MYCPBP
Gene Symbols: DENND4A
Molecular weight: 213,704 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
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DENND4A iso3

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein