PMCA4 Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of rat Ortholog: 13q13
Cellular Component:  basolateral plasma membrane; glutamatergic synapse; intracellular membrane-bounded organelle; membrane; membrane raft; plasma membrane; presynaptic active zone membrane; protein-containing complex; sarcolemma; sperm flagellum; sperm principal piece; T-tubule; Z disc
Molecular Function:  ATP binding; ATP hydrolysis activity; calcium ion transmembrane transporter activity; calmodulin binding; metal ion binding; nitric-oxide synthase binding; nitric-oxide synthase inhibitor activity; P-type calcium transporter activity; PDZ domain binding; protein kinase binding; protein phosphatase 2B binding; scaffold protein binding; sodium channel regulator activity
Biological Process:  calcium ion export; calcium ion transmembrane transport; calcium ion transport; cellular response to acetylcholine; cellular response to epinephrine stimulus; flagellated sperm motility; hippocampus development; intracellular calcium ion homeostasis; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; negative regulation of angiogenesis; negative regulation of arginine catabolic process; negative regulation of blood vessel endothelial cell migration; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of cellular response to vascular endothelial growth factor stimulus; negative regulation of citrulline biosynthetic process; negative regulation of gene expression; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric oxide mediated signal transduction; negative regulation of nitric-oxide synthase activity; negative regulation of the force of heart contraction; neural retina development; positive regulation of cAMP-dependent protein kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein localization to plasma membrane; regulation of cell cycle G1/S phase transition; regulation of cytosolic calcium ion concentration; regulation of transcription by RNA polymerase II; response to hydrostatic pressure; spermatogenesis; urinary bladder smooth muscle contraction
Reference #:  Q64542 (UniProtKB)
Alt. Names/Synonyms: AT2B4; Atp2b4; ATPase, Ca++ transporting, plasma membrane 4; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 4; Plasma membrane calcium-transporting ATPase 4; PMCA4
Gene Symbols: Atp2b4
Molecular weight: 133,094 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene