RASGRF1 Promotes the exchange of Ras-bound GDP by GTP. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 8q31
Cellular Component:  apical dendrite; apicolateral plasma membrane; basolateral plasma membrane; cytoplasm; cytosol; growth cone; neuronal cell body; plasma membrane
Molecular Function:  glutamate receptor binding; GTPase activator activity; protein binding; protein C-terminus binding; protein kinase binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  activation of GTPase activity; cell proliferation; cellular response to antibiotic; cellular response to insulin stimulus; neuron projection development; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; regulation of neuronal synaptic plasticity; regulation of NMDA receptor activity; regulation of Rac protein signal transduction; regulation of Ras protein signal transduction; regulation of Rho protein signal transduction; regulation of synaptic plasticity; response to amphetamine; response to endoplasmic reticulum stress; small GTPase mediated signal transduction
Reference #:  P28818 (UniProtKB)
Alt. Names/Synonyms: GNRP; Guanine nucleotide-releasing protein; P140 Ras-GRF; RAS protein-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Rasgrf1; RGRF1
Gene Symbols: Rasgrf1
Molecular weight: 142,667 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene