TRPV4 Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Together with PKD2, forms mechano- and thermosensitive channels in cilium. Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes. Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes. Together with AQP5, controls regulatory volume decrease in salivary epithelial cells. Required for normal development and maintenance of bone and cartilage. Isoform 5: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. Isoform 2: Lacks channel activity, due to impaired oligomerization and intracellular retention. Isoform 4: Lacks channel activity, due to impaired oligomerization and intracellular retention. Isoform 6: Lacks channel activity, due to impaired oligomerization and intracellular retention. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component:  adherens junction; cell junction; cell projection; cell surface; cilium; cortical actin cytoskeleton; cytoplasmic vesicle; filopodium; focal adhesion; growth cone; integral component of membrane; integral component of plasma membrane; lamellipodium; membrane; plasma membrane; ruffle membrane
Molecular Function:  actin binding; actin filament binding; alpha-tubulin binding; ATP binding; beta-tubulin binding; calcium channel activity; calmodulin binding; cation channel activity; identical protein binding; ion channel activity; lipid binding; metal ion binding; microtubule binding; nucleotide binding; osmosensor activity; protein binding; protein kinase binding; protein kinase C binding; SH2 domain binding; stretch-activated, cation-selective, calcium channel activity
Biological Process:  actin cytoskeleton reorganization; actin filament organization; blood vessel endothelial cell delamination; calcium ion import; calcium ion transmembrane transport; calcium ion transport; cartilage development involved in endochondral bone morphogenesis; cell-cell junction assembly; cellular calcium ion homeostasis; cellular hypotonic response; cellular hypotonic salinity response; cellular response to heat; cellular response to osmotic stress; cortical microtubule organization; diet induced thermogenesis; energy homeostasis; glucose homeostasis; hyperosmotic salinity response; hypotonic response; ion transport; microtubule polymerization; multicellular organismal water homeostasis; negative regulation of brown fat cell differentiation; negative regulation of neuron projection development; negative regulation of transcription by RNA polymerase II; osmosensory signaling pathway; positive regulation of chemokine (C-C motif) ligand 5 production; positive regulation of chemokine (C-X-C motif) ligand 1 production; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of interleukin-6 secretion; positive regulation of JNK cascade; positive regulation of macrophage chemotaxis; positive regulation of macrophage inflammatory protein 1 alpha production; positive regulation of microtubule depolymerization; positive regulation of monocyte chemotactic protein-1 production; positive regulation of vascular permeability; regulation of response to osmotic stress; response to insulin; response to osmotic stress; signal transduction involved in regulation of aerobic respiration; transmembrane transport; vasopressin secretion
Reference #:  Q9EPK8 (UniProtKB)
Alt. Names/Synonyms: 0610033B08Rik; MGC150050; Osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; OTR; OTRPC4; OTTMUSP00000015421; OTTMUSP00000015422; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily V, member 4; Transient receptor potential protein 12; Trp; TRP12; TrpV4; trpv4 channel; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL-2; Vrl2; Vroac
Gene Symbols: Trpv4
Molecular weight: 98,027 Da
Basal Isoelectric point: 6.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TRPV4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene