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DGKA
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Belongs to the eukaryotic diacylglycerol kinase family. Lymphocytes and oligodendroglial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis |
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Cellular Component:
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Molecular Function:
ATP binding; calcium ion binding; NAD+ kinase activity
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Biological Process:
protein kinase C-activating G protein-coupled receptor signaling pathway
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Reference #:
P20192
(UniProtKB)
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Alt. Names/Synonyms: 80 kDa diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK-alpha; DGKA; Diacylglycerol kinase alpha; Diglyceride kinase alpha
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Gene Symbols: DGKA
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Molecular weight:
82,606 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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