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AGBL5
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Belongs to the peptidase M14 family. Expressed in brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.17.-; Protease |
| Chromosomal Location of human Ortholog: 2p23.3 |
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Cellular Component:
cytoplasm; cytosol; intercellular bridge; microtubule cytoskeleton; midbody; mitotic spindle; nucleus
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Molecular Function:
metallocarboxypeptidase activity; tubulin binding; zinc ion binding
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Biological Process:
C-terminal protein deglutamylation; defense response to virus; protein branching point deglutamylation; protein deglutamylation; protein side chain deglutamylation; proteolysis
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Disease: Retinitis Pigmentosa 75
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Reference #:
Q8NDL9
(UniProtKB)
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Alt. Names/Synonyms: AGBL5; ATP/GTP binding protein like 5; ATP/GTP binding protein-like 5; ATP/GTP-binding protein-like 5; CBPC5; CCP5; cytosolic carboxypeptidase 5; Cytosolic carboxypeptidase-like protein 5; FLJ21839; RP75
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Gene Symbols: AGBL5
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Molecular weight:
97,534 Da
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Basal Isoelectric point:
9.34
Predict pI for various phosphorylation states
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