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CRYAB
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373). Note: This description may include information from UniProtKB.
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| Protein type: Chaperone; Heat shock protein |
| Chromosomal Location of rat Ortholog: 8q23 |
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Cellular Component:
actin filament bundle; axon; cardiac myofibril; cell surface; contractile fiber; cytoplasm; cytosol; dendritic spine; extracellular region; I band; lysosome; M band; mitochondrion; nucleus; perikaryon; plasma membrane; protein-containing complex; synaptic membrane; Z disc
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Molecular Function:
amyloid-beta binding; cytoskeletal protein binding; identical protein binding; metal ion binding; microtubule binding; protein binding; protein homodimerization activity; protein-containing complex binding; structural constituent of eye lens; structural molecule activity; unfolded protein binding
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Biological Process:
apoptotic process involved in morphogenesis; camera-type eye development; cellular response to gamma radiation; lens development in camera-type eye; microtubule polymerization or depolymerization; muscle organ development; negative regulation of amyloid fibril formation; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of intracellular transport; negative regulation of protein-containing complex assembly; negative regulation of reactive oxygen species metabolic process; protein folding; protein refolding; protein stabilization; regulation of programmed cell death; response to estradiol; response to heat; response to hydrogen peroxide; response to hypoxia; stress-activated MAPK cascade; tubulin complex assembly
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Reference #:
P23928
(UniProtKB)
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Alt. Names/Synonyms: AACRYA; alpha B-crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; Cryab; crystallin, alpha B; Crystallin, alpha polypeptide 2
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Gene Symbols: Cryab
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Molecular weight:
20,089 Da
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Basal Isoelectric point:
6.76
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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