CRYAB May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373). Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 8q23
Cellular Component:  actin filament bundle; axon; cardiac myofibril; cell surface; contractile fiber; cytoplasm; cytosol; dendritic spine; Golgi apparatus; I band; M band; microtubule cytoskeleton; mitochondrion; nucleus; perikaryon; plasma membrane; postsynaptic density; protein-containing complex; synapse; synaptic membrane; Z disc
Molecular Function:  amyloid-beta binding; cytoskeletal protein binding; identical protein binding; metal ion binding; microtubule binding; protein binding; protein homodimerization activity; protein-containing complex binding; structural constituent of eye lens; unfolded protein binding
Biological Process:  aging; apoptotic process involved in morphogenesis; camera-type eye development; cellular response to gamma radiation; lens development in camera-type eye; microtubule polymerization or depolymerization; multicellular organism aging; muscle organ development; negative regulation of amyloid fibril formation; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gene expression; negative regulation of intracellular transport; negative regulation of protein homooligomerization; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription, DNA-templated; protein folding; protein homooligomerization; protein stabilization; regulation of cell death; response to estradiol; response to hydrogen peroxide; response to hypoxia; stress-activated MAPK cascade; tubulin complex assembly
Reference #:  P23928 (UniProtKB)
Alt. Names/Synonyms: AACRYA; alpha B-crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; Cryab; crystallin, alpha B; Crystallin, alpha polypeptide 2
Gene Symbols: Cryab
Molecular weight: 20,089 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene