AT1 Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Liver, lung, adrenal and adrenocortical adenomas. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 13 A3.2|13 13.19 cM
Cellular Component:  basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; dendrite; endomembrane system; endosome; Golgi apparatus; integral component of membrane; membrane; organelle outer membrane; plasma membrane; recycling endosome
Molecular Function:  angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; D1 dopamine receptor binding; G protein-coupled receptor activity; protein binding; protein heterodimerization activity; protein kinase binding
Biological Process:  activation of Janus kinase activity; angiotensin-activated signaling pathway; blood vessel development; brain renin-angiotensin system; calcium-mediated signaling; cell chemotaxis; cellular response to dexamethasone stimulus; dopamine biosynthetic process; drinking behavior; G protein-coupled receptor signaling pathway; heart development; inflammatory response; kidney development; negative regulation of smooth muscle cell apoptotic process; phospholipase C-activating angiotensin-activated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of blood pressure; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of calcium ion import across plasma membrane; positive regulation of cell proliferation; positive regulation of cellular protein metabolic process; positive regulation of cholesterol esterification; positive regulation of cytokine secretion; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of phospholipase A2 activity; positive regulation of receptor recycling; positive regulation of superoxide anion generation; regulation of pH; regulation of renal output by angiotensin; regulation of smooth muscle cell apoptotic process; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; regulation of vasoconstriction; renin secretion into blood stream; renin-angiotensin regulation of aldosterone production; response to estrogen; Rho protein signal transduction; signal transduction; vasoconstriction
Reference #:  P29754 (UniProtKB)
Alt. Names/Synonyms: 1810074K20Rik; AG2S; Agt; Agt1ar; Agtr; Agtr-1a; Agtr1; Agtr1a; AGTRA; AI551199; angiotensin II receptor type 1; angiotensin II receptor, type 1a; Angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; Angt; Angtr-1a; AT1; AT1A; AT2R1; AT2R1A; MGC37610; OTTMUSP00000000614; Type-1A angiotensin II receptor
Gene Symbols: Agtr1a
Molecular weight: 40,856 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
Select Structure to View Below

AT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene