POLL DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. Belongs to the DNA polymerase type-X family. Expressed in a number of tissues. Abundant in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Lyase; Transferase
Chromosomal Location of human Ortholog: 10q24.32
Cellular Component:  nucleoplasm; nucleus; site of double-strand break
Molecular Function:  5'-deoxyribose-5-phosphate lyase activity; DNA binding; DNA-directed DNA polymerase activity; metal ion binding; protein binding
Biological Process:  base-excision repair, gap-filling; DNA biosynthetic process; DNA replication; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; nucleotide-excision repair; somatic hypermutation of immunoglobulin genes
Reference #:  Q9UGP5 (UniProtKB)
Alt. Names/Synonyms: BETAN; DNA polymerase beta-2; DNA polymerase beta-N; DNA polymerase kappa; DNA polymerase lambda; DPOLL; FLJ46002; Pol beta2; Pol Lambda; POLKAPPA; POLL; polymerase (DNA directed), lambda; polymerase (DNA) lambda
Gene Symbols: POLL
Molecular weight: 63,482 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein