SHLD2
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. Belongs to the SHLD2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Chromosomal Location of human Ortholog: 10q23.2 |
Cellular Component:
actin cytoskeleton; chromatin; chromosome; nucleoplasm; nucleus; site of double-strand break
|
Molecular Function:
protein binding
|
Biological Process:
DNA repair; negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; positive regulation of isotype switching; regulation of double-strand break repair via homologous recombination; somatic diversification of immunoglobulins involved in immune response; telomere maintenance in response to DNA damage
|
Reference #:
Q86V20
(UniProtKB)
|
Alt. Names/Synonyms: bA163M19.1; FA35A; FAM35A; FAM35A1; family with sequence similarity 35 member A; family with sequence similarity 35, member A; hypothetical protein LOC54537; MGC5560; Protein FAM35A; RINN1-REV7-interacting novel NHEJ regulator 2; RINN2; Shield complex subunit 2; Shieldin complex subunit 2; SHLD2
|
Gene Symbols: SHLD2
|
Molecular weight:
93,705 Da
|
Basal Isoelectric point:
6.41
Predict pI for various phosphorylation states
|