TTK Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Present in rapidly proliferating cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); TTK family
Chromosomal Location of mouse Ortholog: 9|9 E2
Cellular Component:  cytoplasm; kinetochore; membrane; nucleus; spindle
Molecular Function:  ATP binding; kinase activity; kinetochore binding; nucleotide binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  chromosome segregation; chromosome separation; female meiosis chromosome segregation; meiotic spindle assembly checkpoint; mitotic cell cycle checkpoint; mitotic spindle assembly checkpoint; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; protein autophosphorylation; protein localization to chromosome; protein localization to kinetochore; protein localization to meiotic spindle midzone; protein phosphorylation
Reference #:  P35761 (UniProtKB)
Alt. Names/Synonyms: AL022661; CT96; Dual specificity protein kinase TTK; ESK; Esk1; Mps1; PYT; Ttk; Ttk protein kinase
Gene Symbols: Ttk
Molecular weight: 96,211 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
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Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene