TLK2
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); TLK family |
Chromosomal Location of mouse Ortholog: 11|11 E1 |
Cellular Component:
cytoplasm; cytoskeleton; intermediate filament; nucleus; perinuclear region of cytoplasm
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Molecular Function:
ATP binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; cell differentiation; cellular response to gamma radiation; chromatin organization; chromosome segregation; DNA damage response; intracellular signal transduction; localization; multicellular organism development; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; regulation of chromatin organization; spermatogenesis
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Reference #:
O55047
(UniProtKB)
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Alt. Names/Synonyms: 4933403M19Rik; PKU; PKU-alpha; PKUalpha; protein kinase U-alpha; Serine/threonine-protein kinase tousled-like 2; Tlk; Tlk2; Tousled-like kinase 2; tousled-like kinase 2 (Arabidopsis)
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Gene Symbols: Tlk2
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Molecular weight:
82,261 Da
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Basal Isoelectric point:
8.51
Predict pI for various phosphorylation states
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