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NEK11 iso4
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 3q22.1 |
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Cellular Component:
nucleolus; nucleoplasm; nucleus
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Molecular Function:
ATP binding; metal ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
intracellular signal transduction; mitotic intra-S DNA damage checkpoint signaling; protein phosphorylation; regulation of mitotic cell cycle phase transition
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Reference #:
Q8NG66-4
(UniProtKB)
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Alt. Names/Synonyms: FLJ23495; NEK11; NEK11 iso4; Never in mitosis A-related kinase 11; NIMA (never in mitosis gene a)- related kinase 11; NIMA related kinase 11; NimA-related protein kinase 11; OTTHUMP00000216112; OTTHUMP00000216137; OTTHUMP00000216138; OTTHUMP00000216139; OTTHUMP00000216140; OTTHUMP00000216604; Q8NG66-4; Serine/threonine-protein kinase Nek11; serine/threonine-protein kinase Nek11 isoform 3
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Gene Symbols: NEK11
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Molecular weight:
68,880 Da
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Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
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