DOK3 iso2 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function. Belongs to the DOK family. Type A subfamily. Expressed in spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component:  ficolin-1-rich granule membrane; plasma membrane; secretory granule membrane
Molecular Function:  protein binding
Biological Process:  neutrophil degranulation; Ras protein signal transduction
Reference #:  Q7L591-2 (UniProtKB)
Alt. Names/Synonyms: Docking protein 3; docking protein 3 isoform 2; docking protein 3 isoform 3; Dok-like protein; DOK3; DOK3 iso2; DOKL; downstream of tyrosine kinase 3; FLJ22570; FLJ39939; OTTHUMP00000161439; OTTHUMP00000223809; OTTHUMP00000223810; OTTHUMP00000223811; OTTHUMP00000223816; Q7L591-2; Q7L591-3; Q7L591-4
Gene Symbols: DOK3
Molecular weight: 23,255 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling
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DOK3 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept