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DOK3 iso2
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function. Belongs to the DOK family. Type A subfamily. Expressed in spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 5q35.3 |
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Cellular Component:
cytoplasm; ficolin-1-rich granule membrane; plasma membrane; secretory granule membrane
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Molecular Function:
protein binding
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Biological Process:
positive regulation of MAPK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q7L591-2
(UniProtKB)
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Alt. Names/Synonyms: Docking protein 3; docking protein 3 isoform 2; docking protein 3 isoform 3; Dok-like protein; DOK3; DOK3 iso2; DOKL; downstream of tyrosine kinase 3; FLJ22570; FLJ39939; OTTHUMP00000161439; OTTHUMP00000223809; OTTHUMP00000223810; OTTHUMP00000223811; OTTHUMP00000223816; Q7L591-2; Q7L591-3; Q7L591-4
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Gene Symbols: DOK3
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Molecular weight:
23,255 Da
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Basal Isoelectric point:
8.51
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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