PLK2 Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Expressed at higher level in the fetal lung, kidney, spleen and heart. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 2q14
Cellular Component:  centriole; centrosome; chromatin; cytoplasm; dendrite; nucleus; spindle pole
Molecular Function:  ATP binding; ATP-dependent protein binding; protein binding; protein serine/threonine kinase activity; protein-containing complex binding
Biological Process:  G1/S transition of mitotic cell cycle; long-term synaptic depression; long-term synaptic potentiation; memory; mitotic cell cycle; mitotic cell cycle checkpoint; mitotic spindle organization; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic process in bone marrow; negative regulation of cellular senescence; negative regulation of dendritic spine development; peptidyl-serine phosphorylation; positive regulation of autophagy; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; protein phosphorylation; Rap protein signal transduction; Ras protein signal transduction; regulation of centriole replication; regulation of cytokinesis; regulation of synaptic plasticity
Reference #:  Q9R012 (UniProtKB)
Alt. Names/Synonyms: PLK-2; Plk2; polo-like kinase 1; Polo-like kinase 2; polo-like kinase 2 (Drosophila); Serine/threonine-protein kinase PLK2; Serine/threonine-protein kinase SNK; Serum-inducible kinase; Snk
Gene Symbols: Plk2
Molecular weight: 77,920 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
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Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene