PLK2 a kinase of the PLK family. Participates in a mitotic checkpoint in which p53-dependent activation Plk2 prevents mitotic catastrophe following spindle damage. Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. Apparently plays a role for Plk2 in the cell cycle. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 13|13 D2.1
Cellular Component:  cell projection; centriole; centrosome; chromatin; cytoplasm; cytoskeleton; dendrite; nucleus; spindle pole
Molecular Function:  ATP binding; ATP-dependent protein binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity
Biological Process:  G1/S transition of mitotic cell cycle; long-term synaptic depression; long-term synaptic potentiation; memory; mitotic cell cycle; mitotic cell cycle checkpoint; mitotic spindle organization; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic process in bone marrow; negative regulation of cellular senescence; negative regulation of dendritic spine development; peptidyl-serine phosphorylation; phosphorylation; positive regulation of autophagy; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; protein phosphorylation; Rap protein signal transduction; Ras protein signal transduction; regulation of centriole replication; regulation of cytokinesis; regulation of synaptic plasticity
Reference #:  P53351 (UniProtKB)
Alt. Names/Synonyms: PLK-2; Plk2; Polo-like kinase 2; polo-like kinase 2 (Drosophila); Serine/threonine-protein kinase PLK2; Serine/threonine-protein kinase SNK; Serum-inducible kinase; Snk
Gene Symbols: Plk2
Molecular weight: 77,812 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
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Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene