PLK4 Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.21; Kinase, protein; Nucleolus; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3|3 B
Cellular Component:  centriole; centrosome; cytoplasm; cytoskeleton; cytosol; deuterosome; nucleolus; nucleus; XY body
Molecular Function:  ATP binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  centriole replication; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; phosphorylation; positive regulation of centriole replication; protein phosphorylation; trophoblast giant cell differentiation
Reference #:  Q64702 (UniProtKB)
Alt. Names/Synonyms: 1700028H20; AI385771; PLK-4; Plk4; Polo-like kinase 4; polo-like kinase 4 (Drosophila); Sak; serine/threonine kinase 18; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase Sak; Stk18
Gene Symbols: Plk4
Molecular weight: 103,746 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
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PLK4

Protein Structure Not Found.


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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene