NEK4 Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 14|14 B
Cellular Component:  cell projection; ciliary basal body; ciliary plasm; ciliary rootlet; ciliary transition zone; cytoplasm; cytosol
Molecular Function:  ATP binding; kinase activity; manganese ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cellular response to DNA damage stimulus; mitotic cell cycle; phosphorylation; positive regulation of DNA-templated transcription; protein phosphorylation; regulation of cellular senescence; regulation of response to DNA damage stimulus
Reference #:  Q9Z1J2 (UniProtKB)
Alt. Names/Synonyms: Nek4; Never in mitosis A-related kinase 4; NIMA (never in mitosis gene a)-related expressed kinase 4; NIMA-related expressed kinase 4; NIMA-related kinase 4; NimA-related protein kinase 4; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase Nek4; Stk2
Gene Symbols: Nek4
Molecular weight: 88,994 Da
Basal Isoelectric point: 6.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene