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NEK4
Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; NEK family; NEK4 subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 14|14 B |
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Cellular Component:
cell projection; ciliary basal body; ciliary plasm; ciliary rootlet; ciliary transition zone; cytoplasm; cytosol
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Molecular Function:
ATP binding; kinase activity; manganese ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; cell division; DNA damage response; mitotic cell cycle; phosphorylation; positive regulation of DNA-templated transcription; protein phosphorylation; regulation of cellular senescence
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Reference #:
Q9Z1J2
(UniProtKB)
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Alt. Names/Synonyms: Nek4; Never in mitosis A-related kinase 4; NIMA (never in mitosis gene a)-related expressed kinase 4; NIMA-related expressed kinase 4; NIMA-related kinase 4; NimA-related protein kinase 4; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase Nek4; Stk2
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Gene Symbols: Nek4
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Molecular weight:
88,994 Da
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Basal Isoelectric point:
6.93
Predict pI for various phosphorylation states
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